The Manibus scenario is the game's introductory PvE (Player vs. Environment) experience, focusing on co-op exploration, resource gathering, and boss fights against powerful entities like the main boss, Manibus, with difficulties ranging from Novice to Hard, and features like Prime Wars and unique Deviations, setting the stage for players to learn core mechanics before moving to later scenarios.

The Way of Winter is a major PvE scenario. It drops you into the harsh Snowy Realm in the far north of Nalcott, where extreme temperatures, freezing cold and blistering heat become one of your biggest challenges on top of the usual survival mechanics like stamina, hydration, and sanity.

Endless Dream is a PvE scenario in Once Human where the world of Nalcott becomes trapped in a distorted dreamscape. The environment is overrun by expanding Dream Zones that transform the landscape with dangerous anomalies and nightmare-like effects. Meta-Humans must work together to purge these zones, defeat the entities sustaining the nightmare, and ultimately locate the Original Entity responsible for the dream in order to restore reality.

Prismverse’s Clash is a PvP-focused game mode centered around large-scale faction warfare. Players choose between two rival factions. Mayfly or Rosetta and battle across contested zones to secure powerful entities called Prism Deviations. The main objective is to capture these Prism Deviations and convert them into Prism Energy, which contributes to your faction’s total score. The faction with the most energy at the end of the scenario wins. Combat is constant in designated conflict areas, encouraging teamwork, base-building, and strategic fights, but players don’t lose their gear upon death, making it more accessible and fast-paced.